Effects of conventional and a novel colonic-release bile acid sequestrant, A3384, on fibroblast growth factor 19 and bile acid metabolism in healthy volunteers and patients with bile acid diarrhoea.
We investigated how a novel colonic-release formulation of colestyramine, A3384, impacts bile acid metabolism and bowel function in patients with primary bile acid diarrhoea (BAD).
In a double-blind study, participants received either A3384 or a placebo for two weeks. While conventional bile acid sequestrants lowered serum fibroblast growth factor 19 (FGF19) and increased bile acid production, A3384 did not exhibit this effect.
However, A3384 did improve diarrhoeal symptoms, showing promise as a better-tolerated treatment option for BAD.
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Most Useful Reviews
7.5
Energy and relief
This taurine is of high quality and comes in a large volume. It has no pronounced taste. Since I began taking it, the heaviness after eating has vanished, my bowel movements have improved, blood pressure has normalised, and I feel more energised.
Read More
6
Improved bile flow
It dissolves well in water and, for me, it has enhanced the outflow of bile related to irritable bowel syndrome.
Effects of conventional and a novel colonic-release bile acid sequestrant, A3384, on fibroblast growth factor 19 and bile acid metabolism in healthy volunteers and patients with bile acid diarrhoea.
We investigated how a novel colonic-release formulation of colestyramine, A3384, impacts bile acid metabolism and bowel function in patients with primary bile acid diarrhoea (BAD).
In a double-blind study, participants received either A3384 or a placebo for two weeks. While conventional bile acid sequestrants lowered serum fibroblast growth factor 19 (FGF19) and increased bile acid production, A3384 did not exhibit this effect.
However, A3384 did improve diarrhoeal symptoms, showing promise as a better-tolerated treatment option for BAD.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
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Negative Reviews
7.5
Energy and relief
This taurine is of high quality and comes in a large volume. It has no pronounced taste. Since I began taking it, the heaviness after eating has vanished, my bowel movements have improved, blood pressure has normalised, and I feel more energised.
Read More
6
Improved bile flow
It dissolves well in water and, for me, it has enhanced the outflow of bile related to irritable bowel syndrome.
Read More
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